Gene mutation speeds up the aging process (article)

Gene mutation speeds up the aging process
Scientists discover why some people age earlier than others
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updated 1:40 p.m. ET, Sun., Feb. 7, 2010

LONDON – Scientists have found specific genetic variants which may explain why some people age earlier than others and say their findings have important implications for understanding cancer and age-related diseases.

Dutch and British researchers analyzed more than 500,000 genetic variations from human gene maps and found that people with particular variants near a gene called TERC were likely to be biologically older by 3 to 4 years.

“What our study suggests is that some people are genetically programed to age at a faster rate. The effect was quite considerable in those with the variant,” said Tim Spector from King’s College London, who co-led the study.

In a study published in the Nature Genetics journal, the scientists explained that there are two forms of aging — chronological aging, counted in years, and biological aging, in which the cells of some people are older, or younger, than their chronological age.

“There is accumulating evidence that the risk of age-associated diseases including heart disease and some types of cancers are more closely related to biological rather than chronological age,” said Nilesh Samani, a cardiology professor at Britain’s Leicester University, who worked on the study.

The researchers studied structures called telomeres — protective caps on the ends of chromosomes whose length is associated with cell aging.

Fraying or shortening of telomeres can lead to premature aging and cancer, a finding that helped win the 2009 Nobel Prize for Medicine for three American scientists who discovered an enzyme, telmorase, that helps prevent such fraying.

Scientists have known for some time that the TERC gene, which regulates the length of telomeres, plays a key role in aging and cancer, but Spector said the importance of this study was that it identified particular variants of it in humans that suggest earlier aging is more likely.

“We have known about telomeres for a long time, but finding a common variant in humans that changes them is an important step,” he said in a telephone interview.

People carrying a particular variant of the gene had shorter telomeres, and appeared biologically older, the scientists said.

“Given the association of shorter telomeres with age-associated diseases, the finding raises the question whether individuals carrying the variant are at greater risk of developing such diseases,” said Samani.